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探讨瘦素（leptin）对人脑胶质瘤U87MG细胞迁移及侵袭能力的影响及其机制。方法：Leptin处理U87MG细胞，采用细胞划痕实验检测U87MG细胞的迁移能力，Transwell实验检测U87MG细胞的侵袭能力，RT-PCR及Western blotting法检测U87MG细胞中MMP-2及MMP-9 mRNA和蛋白的表达。结果：Leptin明显促进U87MG细胞迁移能力\[（152.42±3...
THE RELATIONSHIP BETWEEN LEPTIN AND INSULIN RESISTANCE IN IRANIAN OBESE CHILDREN
Leptin INSULIN CHILDREN
2010/1/5
Background: Leptin is an adipocyte- derived hormone that plays an important role in the pathogenesis of obesity. Obesity is associated with insulin resistance and hyperinsulinemia. Insulin resistance ...
LEPTIN: A NEW ADYPOCYTE HORMONE AND ITS ROLE IN THE OBESITY
Adipocyte Anthropometric measurement Childhood obesity Regression analysis
2010/1/5
Leptin is a 16-kD protein which is secreted from white adipocytes and, its discovery has generated enormous interest in the regulation of energy balance. Leptin has been implicated in the regulation o...
Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis
Rheumatoid arthritis Leptin Resistin Body mass index Disease activity
2009/7/6
Aim: Adipocytokines are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (R...
A Role of Leptin in Psoriasis?
Department of Dermatology, Faculty of Medicine,Dokuz Eylul University,İ zmir-TURKEY Department of Biochemistry,Faculty of Medicine,Pamukkale University,Denizli-TURKEY
2009/6/17
Aim: Although there is evidence of a positive association between psoriasis and body mass index (BMI) and leptin is known to play a part in the regulation of the immune system, the relationship betwee...
THE EFFECT OF DIFFERENT EXERCISE PROTOCOLS ON LEPTIN LEVELS AND REGIONAL LEFT VENTRICULAR DIASTOLIC HEART FUNCTION AMONG PROFESSIONAL SWIMMERS – A COMPARISON WITH UNTRAINED SUBJECTS: A DOPPLER TISSUE IMAGING STUDY
physical exercise leptin diastolic heart function Tissue Doppler Echocardiography
2009/4/2
Background: It is assumed that leptin affects the circulatory system. The aim of this study was to assess the influence of chronic, dynamic and static physical effort on leptin levels and regional d...
Leptin在大鼠肝缺血/再灌注介导的肠道损伤中的作用
Leptin 大鼠 肝缺血/再灌注介导 肠道损伤
2009/2/9
目的: 研究瘦素(leptin)在肝缺血/再灌注(H-I/R)后肠道内的表达变化, 并探讨leptin在H-I/R介导的肠道损伤中的作用. 方法: 建立大鼠70% H-I/R模型, 大鼠随机分成5组, 每组9只, 依次为假手术(Sham)组、肝缺血60 min/再灌注60 min (I60'R60')组、I60'R150'组、I60'R240'组和I60'R360'组. 采用酶比色法检测损伤后血清...
Relationship between Serum Umbilical Cord and Maternal Leptin and Adiponectin Concentrations with Fetal Growth Parameters
Serum umbilical Maternal leptin Fetal growth
2010/4/9
Background: Pregnancy and accelerated fetal growth always are related with major metabolic changes and body fat redistribution and adiponectin is one of principle adipocyte hormones, so studying adipo...