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The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
Cloning and characterization of GUKHolder, a novel synaptically expressed protein that interacts with Discs -Large and SCRIBBLE at the Drosophila neuromuscular junction
Neurons spatial arrangement protein tumor protein complex enzyme
2014/12/11
Synaptic transmission between a neuron and its target is crucially dependent upon the precise spatial arrangement of proteins in the pre- and postsynaptic apparatus. PDZ domain-containing proteins suc...
Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction
Neurons circuit static core
2014/12/11
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
Postsynaptic mechanisms during synaptic plasticity at the Drosophila neuromuscular junction
Synaptic plasticity cells molecules cells nerve muscle
2014/12/11
The ability of established synaptic connections to strengthen and weaken (synapse plasticity) underlies higher order behavior such as learning and memory. Several gaps remain in our understanding of t...
Extracellular electrical signals in a neuron-surface junction: model of heterogeneous membrane conductivity
Neuron extracellular electrical signals cell-surface junction transmembrane current
2012/2/28
Signals recorded from neurons with extracellular planar sensors have a wide range of waveforms and amplitudes. This variety is a result of different physical conditions affecting the ion currents thro...
Modeling of the gap junction of pancreatic β-cells and the robustness of insulin secretion
pancreatic β-cells gap junctions synchronization robustness
2010/12/2
Pancreatic β-cells are interconnected by gap junctions, which allow small molecules to pass from cell to cell. In spite of the importance of the gap junctions in cellular communication, modeling studi...