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Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders
Neural development FOXP transcription factors common human regulate gene protein the FOXP2 gene
2018/3/5
FOXP transcription factors play important roles in neurodevelopment, but little is known about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate gene expression by ...
Next-gen sequencing identifies non-coding variation disrupting miRNA binding sites in neurological disorders
SCZ ASD
2017/8/28
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their
prevalence and potential severity for quality of life. While large-scal...
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Genetic risk autism spectrum disorders neuropsychiatric variation general population
2016/5/3
Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of that risk are unclear in people not ascertained for neuropsychiatric sym...
Emotional language processing in autism spectrum disorders: a systematic review
autism spectrum disorders asperger syndrome
2015/12/18
In his first description of Autism Spectrum Disorders (ASD), Kanner emphasized emotional
impairments by characterizing children with ASD as indifferent to other people, selfabsorbed, emotionall...
Are developmental disorders like cases of adult brain damage? Implications from connectionist modelling
Acquired and developmental disorders connectionist models modularity past tense reading
2015/6/19
It is often assumed that similar domain-specific behavioural impairments found in cases of adult brain damage and developmental disorders correspond to similar underlying causes, and can serve as conv...
Emotional language processing in autism spectrum disorders: a systematic review
autism spectrum disorders asperger syndrome social emotion affect language
2015/5/13
In his first description of Autism Spectrum Disorders (ASD), Kanner emphasized emotional impairments by characterizing children with ASD as indifferent to other people, selfabsorbed, emotionally cold,...
Shining a light on CNTNAP2: complex functions to complex disorders
CNTNAP2 neurogenetics language disorder
2015/5/6
The genetic basis of complex neurological disorders involving language are poorly understood, partly due to the multiple additive genetic risk factors that are thought to be responsible. Furthermore, ...
Processing of Emotion Words by Patients with Autism Spectrum Disorders: Evidence from Reaction Times and EEG
Autism spectrum disorders EEG ERP Emotion words LPC Lexical decision task
2015/5/5
This study investigated processing of emotion words in autism spectrum disorders (ASD) using reaction times and event-related potentials (ERP). Adults with (n = 21) and without (n = 20) ASD performed ...
Neurogenomics of speech and language disorders: the road ahead
exome genome FOXP2 functional validation language next-generation sequencing neurodevelopmental disorders speech
2015/4/24
Next-generation sequencing is set to transform the discovery of genes underlying neurodevelopmental disorders, and so off er important insights into the biological bases of spoken language. Success wi...
A Perceptual–Motor Deficit Predicts Social and Communicative Impairments in Individuals With Autism Spectrum Disorders
autism spectrum disorders social deficits perception perceptual–motor integration action capability estimation affordance perception
2015/4/21
Individuals with autism spectrum disorders (ASDs) have known impairments in social and motor skills. Identifying putative underlying mechanisms of these impairments could lead to improved understandin...
Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex
Molecular networks implicated speech-related disorders FOXP2 regulates SRPX2/uPAR complex
2015/4/9
It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental...
Neural correlates of pragmatic language comprehension in autism spectrum disorders
autism functional MRI pragmatics language comprehension voice processing
2015/4/7
Difficulties with pragmatic aspects of communication are universal across individuals with autism spectrum disorders (ASDs).Here we focused on an aspect of pragmatic language comprehension that is rel...
Isolating Intrinsic Processing Disorders from Second Language Acquisition
Second Language Acquisition limited English proficiency Learning Disabilities Diagnostic Inventory
2008/9/24
Differentiating intrinsic processing disorders from extrinsic factors, such as cultural differences and language acquisition proficiency, is a complex issue. Students with limited English proficiency ...