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一种新型重组免疫毒素DT390-Rantes真核表达质粒的构建及功能
2007/7/25
免疫毒素(IT)是一类将生物毒素与导向载体(抗体或细胞因子)连接起来构成的杂合分子，具有特定杀伤某些细胞的能力。随着T细胞的活化，在细胞表面会有许多膜受体表达，现已证实Rantes受体的表达仅限于活化的Th1细胞，而Th2细胞则没有表达，且这种膜受体的表达是稳定和持续的[1][2]，因此，Rantes受体不仅可以作为识别Th1细胞和Th2细胞的标志，也为相关的免疫治疗提供了一个理想的靶位。本研究以...
RANTES Production from Mononuclear Cells in Response to the Specific Allergen in Asthma Patients
asthma chemokine eosinophil mononuclear cells platelets RANTES
2010/11/19
Background: Eosinophils are considered to be the major inflammatory cells in asthma. Since regulated on activation, normal T expressed and secreted (RANTES) is a potent chemoattractant for various imp...
Inhalant corticosteroids inhibit mechanical strain-induced RANTES and eotaxin production by human airway smooth muscle cells
airway smooth muscle cells eotaxin inhaled corticosteroids mechanical strain RANTES
2010/11/24
The results showed that: (i) mechanical strain, including stretch and compression, stimulated ASM cells to produce RANTES and eotaxin; and (ii) FP and BUD inhibited mechanical strain-induced and TNF-α...
Lack of Association between Atopic Dermatitis and -401A/G Polymorphism in the Promoter Region of the RANTES Gene in Japanese
atopic dermatitis IgE polymorphism RANTES
2010/11/22
Background: Regulated on activation, normal T expressed and secreted (RANTES) has been known to be deeply involved in the pathophysiology of atopic dermatitis (AD). To examine whether a -401A/G polymo...