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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state（图）
唐氏综合症 细胞生物学 全基因组 破坏模仿 衰老样状态
2023/6/6
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Disruptions to embryonic reprogramming alter adult mouse behavior
embryonic reprogramming adult mouse
2016/2/22
Right after fertilization, embryos at the earliest stages of development tell their genes: "Forget what it was like in the sperm or egg where you came from."
When the process of epigenetic reprogramm...
Effects of orbital ellipticity on collisional disruptions of rubble-pile asteroids
Celestial mechanics Methods:numerical Minor planets,asteroids:general Planets and satellites:physical evolution
2015/12/25
The behavior of debris ejected from asteroids after collisional disruptions has significant implications for asteroid evolution. Analytical approximations of the elliptic restricted three-body system ...
Numerically simulating impact disruptions of cohesive glass bead agglomerates using the soft-sphere discrete element method
Asteroids, Surfaces Collisional physics Geological processes Regoliths
2015/12/25
We present our implementation of cohesion in the parallel N-body code pkdgrav in order to model small bodies that are not fully monolithic but that have at least some degree of cohesion. Small bodies ...
Binary near-Earth asteroid formation:Rubble pile model of tidal disruptions
Asteroids Dynamics Rotational dynamics Tides solid body
2015/12/25
We present numerical simulations of near-Earth asteroid (NEA) tidal disruption resulting in bound, mutually orbiting systems. Using a rubble pile model we have constrained the relative likelihoods for...
Supply-chain disruptions have a material effect on company value, but this impact can vary considerably. Thus, it is important for managers and investors to recognize the types of disruptions and the ...
Designing infrastructure with resilience from disruptions and disasters
Designing infrastructure disruptions disasters
2014/10/9
When infrastructure is resilient, it is able to bounce back after a disruption at an acceptable cost and speed. When resilient infrastructure is interdependent, cascading failures between infrastructu...
A Dynamic Navigation Algorithm Considering Network Disruptions
Shortest path dynamic navigation emergency evacuation stochastic disruption priori knowledge
2014/7/23
In traffic network, link disruptions or recoveries caused by sudden accidents, bad weather and traffic congestion, lead to significant increase or decrease in travel times on some network links. Simil...
UNDERSTANDING RESPONSES TO SUPPLY CHAIN DISRUPTIONS: INSIGHTS FROM INFORMATION PROCESSING AND RESOURCE DEPENDENCE PERSPECTIVES
supply chain disruptions important questions repertoire of strategic responses stability motive
2011/10/15
Why, how, and under what conditions do firms respond to supply chain disruptions?These are important questions, given that firms around the world are increasingly exposed to disruptions that impede th...
Combined Generalized Hubbert-Bass Model Approach to Include Disruptions When Predicting Future Oil Production
Generalized Bass Model Hubbert Curve Oil Production
2013/3/8
In a previous study [1] the authors had developed a methodology for predicting global oil production. Briefly, the model accounted for disruptions in production by utilising a series of Hubbert curves...
Combined Generalized Hubbert-Bass Model Approach to Include Disruptions When Predicting Future Oil Production
Generalized Bass Model Hubbert Curve Oil Production
2013/3/8
In a previous study [1] the authors had developed a methodology for predicting global oil production. Briefly, the model accounted for disruptions in production by utilising a series of Hubbert curves...
Sleep Disruptions in Parents of Children and Adolescents with Chronic Illnesses: Prevalence, Causes, and Consequences
caregivers children chronic illness parents sleep
2009/12/21
Objective Provide a comprehensive review of the existing literature on the prevalence, causes, and consequences of sleep disruptions in parents of youth with chronic illnesses. Methods A comprehensive...