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Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are mis...
New gene-editing technique shows promise against sickle cell disease（图）
镰状细胞性贫血 基因编辑技术 一次性治疗
2023/6/21
Ateam of researchers led by scientists from Harvard and the Broad Institute used a new gene-editing technique to successfully treat sickle cell disease in mice. This advancement could one day lead to ...
Acute Lumbar Paraspinal Myonecrosis in Football Players with Sickle Cell Trait: A Case Series
ACUTE LOW BACK PAIN EXERTIONAL SICKLING
2018/4/24
We report six cases of a novel syndrome of acute, exertional low back pain in football players, five in college and one in the National Football League. All six are African Americans with sickle cell ...
Gene editing study reveals possible 'Achilles heel' of sickle cell disease
Gene editing study Achilles heel sickle cell disease
2015/9/25
Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that changes to a small stretch of DNA may circumvent the genetic defect behind sickle cell d...
Use of Continuous Regional Anesthetic for Management of Pediatric Sickle Cell Crisis
Sickle Cell Crisis Regional Anesthesia Pediatric Pain
2013/1/30
Sickle cell patients often find difficulty obtaining adequate treatment of pain. Anti-inflammatory medications, steroids, and opioids can reduce pain; however their use is limited by side effects. We ...
First Presentation of Sickle Cell Anemia in A 3.5-Year-Old Girl:A Case Report
Sickle Cell Anemia
2015/9/25
Sickle cell disease is an inherited disorder of hemoglobin synthesis, which affects many individuals worldwide. Vaso-occlusive, aplastic and sequestration crises are common in a sickle cell child.1 On...
Nitric Oxide and Trace Metals in Relation to Haemoglobin F Concentration in Nigerian Sickle Cell Disease Patients
Sickle cell disease trace metals haemoglobin F oxidants
2010/2/24
Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a ce...
Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria
Sickle cell disease malaria parasitaemia immunoglobulins inflammation haemolysis
2010/1/11
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a mala...
Sickle cell hemoglobin D disease First reported case in IRAN
Sickle cell hemoglobin D IRAN
2009/12/15
A case of sickle cell Hb D disease IS reported in young Iranian male.the father of whom carried an AS sickle cell trait and the mother an AD trait.This disease was diagnosed by Hb electrophoresis.aga...
Many sickle-cell deaths in Africa may be avoidable
sickle-cell deaths Africa bacterial infections
2009/9/15
Children in Africa with sickle cell anaemia are dying unnecessarily from bacterial infections, suggests the largest study of its kind, led by Oxford University researchers. The study, funded by the We...
Hyperbaric Oxygen Therapy in the Treatment of Sickle Cell Leg Ulcers
Sickle Cell wound healing
2009/5/8
Rudge FW. Hyperbaric Oxygen Therapy in the Treatment of Sickle Cell Leg Ulcers. J. Hyperbaric Med 1991; 6(1):1-4.
Amelioration of Sickle Cell Crises With Intensive Hyperbaric Oxygen
Sickle Cell Hyperbaric Oxygenation
2009/5/8
Hart GB, Finklestein JZ, Groncy PK, Meyer GW, Strauss MB. Amelioration of Sickle Cell Crises With Intensive Hyperbaric Oxygen. J. Hyperbaric Med 1991; 6(2):75-85.
Orthodontic Treatment of Patients with Sickle-cell Anemia
Orthodontic Treatment Patients Sickle-cell Anemia
2008/11/17
Sickle-cell anemia is a genetic blood disease characterized by a hemoglobin gene mutation. The genetic failure is basically constituted by replacement of the hemoglobin beta chain in the sixth posit...
A Longitudinal Examination Predicting Emergency Room Use in Children with Sickle Cell Disease and Their Caregivers
emergency room utilization perceptions of disease sickle cell disease
2008/3/25
Objective To examine in a longitudinal investigation perceptions of disease severity among children and adolescents with sickle cell disease (SCD) and their caregivers and to determine whether percept...
Brief Report: Daily Mood as a Mediator or Moderator of the Pain–Sleep Relationship in Children with Sickle Cell Disease
diary mood pain sickle cell disease sleep
2009/12/21
Objective To investigate mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease (SCD). Method Children with SCD (n = 20; aged 8–12 years) completed daily d...