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目的： 研究线粒体膜上ATP敏感钾通道（MitoKATP）开放剂diazoxide和线粒体膜电位（ΔΨm）在缺氧导致的大鼠肺动脉平滑肌细胞内氧自由基的变化及细胞增殖/凋亡失衡中的作用，探索缺氧性肺动脉重建和肺动脉高压形成的发生机制。方法： 取大鼠正常肺组织，分离出肺动脉平滑肌细胞（PASMCs）进行常氧或慢性缺氧培养。将样本分为6组：① 正常对照组；② 线粒体膜上ATP敏感钾通道（MitoKATP...
Effect of classic preconditioning and diazoxide on endothelial function and O 2 and NO generation in the post-ischemic guinea-pig heart
Endothelial dysfunction Nitric oxide Ischemic preconditioning Oxygen free radicals Ischemia Reperfusion
2014/3/31
A hypothesis was tested that a reaction product between superoxide (O2
) and nitric oxide (NO) mediates post-ischemic
coronary endothelial dysfunction that ischemic preconditioning (IPC) protects...