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Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma
aspirin-intolerant asthma bronchial asthma chronic rhinosinusitis prostaglandin D2 prostaglandin E2
2010/11/17
The concentrations of PGD2 were significantly higher in the nasal polyps of the CRS-ATA group. The concentrations of PGE2 were lowest in the nasal polyps of the CRS-AIA group. The PGD2/PGE2 ratio was ...
Role of Prostaglandin D2 and Its Receptors in the Pathophysiology of Asthma
asthma CRTH2 DP eosinophils lipid mediators single nucleotide polymorphisms
2010/11/17
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the ide...
Low Magnesium Concentration in Erythrocytes of Children with Acute Asthma
Asthma Children Magnesium
2010/2/3
Magnesium (Mg) is the second most abundant intracellular cation and is involved in numerous physiological functions, including protein folding, intracellular signaling and enzyme catalysis. It has bee...
Advances in the pathophysiology of bronchial asthma
apoptosis bronchial asthma eosinophils Fas ligand GATA-3 inflammation STAT6 T cells Th2 cytokines
2010/11/25
Asthma is a complex disorder associated with the activation of T lymphocytes and with eosinophil infiltration within the airways. A substantial amount of current research involves the interaction amon...
Current and potential improvements in the treatment of asthma from increased understanding of airway pathophysiology
β-adrenergic receptor agonists anti-IgE antibody anti-interleukin-5 monoclonal antibody asthma corticosteroids leukotriene inhibitors theophylline
2010/11/24
The mainstay of chronic asthma management consists of using pharmacological agents that induce broncho-dilatation, such as short-acting β-adrenergic receptor agonists (bronchodilators or relievers), a...