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Comparative Cytotoxicity of Fludarabine in Human Peripheral Blood Mononuclear Cells and in the Promyelocytic Leukemia Cell Line (HL60)
HL60 MTT assay fludarabine cytotoxicity differentiation
2009/6/23
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
RANTES Production from Mononuclear Cells in Response to the Specific Allergen in Asthma Patients
asthma chemokine eosinophil mononuclear cells platelets RANTES
2010/11/19
Background: Eosinophils are considered to be the major inflammatory cells in asthma. Since regulated on activation, normal T expressed and secreted (RANTES) is a potent chemoattractant for various imp...
Effect of macrolides on the expression of human leukocyte antigen-DR and costimulatory molecules on cultured human mononuclear cells
CD54 CD80 CD86 costimulatory molecules human leukocyte antigen-DR macrolides monocytes
2010/11/25
Although the clinical effectiveness of long-term low-dose administration of macrolides for diffuse pan- bronchiolitis, sinobronchial syndrome, chronic sinusitis and otitis media with effusion has been...
The Effect of Suplatast Tosilate on TARC Production in Peripheral Blood Mononuclear Cells and TARC Plasma Levels
allergic rhinitis chemokines suplatast tosilate TARC
2010/11/22
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: Relationship of local responsiveness to cytokine production by peripheral blood mononuclear cells
allergic rhinitis atopy bronchial asthma bronchial responsiveness interleukin-4 interleukin-5 nasal responsiveness
2010/11/29
To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i) bronchial asthma pati...